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Anti A-G-E with ANTIOXIDANTS & Q10 30 Tablets




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Anti A-G-E with ANTIOXIDANTS & Q10 30 Tablets

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Products Information

Aging is a complex mechanism of progressive and irreversible processes
occurring to molecules, to cells and to the whole organism and ending with
death. Genetic factors and the combination of environmental interactions play
the most important role in its development. The environmental effects, such
as irradiation, toxic chemicals, metal ions, and free radicals play a
determinant role in the development of aging. The mechanism of aging
involves changes in macromolecules caused by free radicals, non-enzymatic
glycosylation and apoptosis.


Adults – Take 2 tablets twice daily, one dose in the morning and one dose
before sleep, or as professionally recommended.

Seek professional health advice if pregnant, lactating, suffering a medical
condition or taking medication before supplementing. In rare cases, some
ingredients may cause an allergic reaction.


Each 4 tablet contain: Grape Seed 3000mg, Mucuna Pruriens 3000mg,  Ginkgo Biloba 2000mg, Milk Thistle 2000mg, Bacopa
Monniera 2000mg, Tumeric 1000mg,  L-Arginine Pyroglutamate 1000mg, Deer Velvet 500mg, L-Glutamine 300mg, Colotrum 200mg, L-Lysine 200mg,  L-Ornithine 150mg, Acetyl-LCarnitine 150mg, Ascorbic acid (Vitamin C) 50mg,  L-Carnosine 50mg, Coenzyme Q10 30mg, Phosphatidyl Serine 20mg, Alpha Lipoic Acid 5mg, Piperine 5mg, Dalpha Tocopherol (Vitamin E) I5iu,

This product contains tableting aids. Some herbal extracts used.

What is Anti A-G-E ?

Aging is a complex mechanism of progressive and irreversible processes
occurring to molecules, to cells and to the whole organism and ending with
death. Genetic factors and the combination of environmental interactions play
the most important role in its development. The environmental effects, such
as irradiation, toxic chemicals, metal ions, and free radicals play a
determinant role in the development of aging. The mechanism of aging
involves changes in macromolecules caused by free radicals, non-enzymatic
glycosylation and apoptosis.
Human serum contains many different antioxidants that may be important in
the maintenance of antioxidant protection. Aging decreases the level of
enzymatic and non-enzymatic antioxidants in plasma. Goraca A. from Institute
of Physiological and Biochemistry in Poland investigated the total antioxidant
capacity in plasma obtained from healthy young and old volunteers in a study
using the ferric reducing antioxidant capacity.
It was found that the total antioxidant capacity of plasma obtained from
healthy young females and males did not differ significantly between each
other and was significantly higher than plasma antioxidant capacity of elderly
volunteers. The results confirmed that plasma antioxidant capacity declines
with the volunteers' age and supplementation of antioxidants could be useful
for enhancement of antioxidant protection in plasma.
Pro-life has developed an innovative product, Anti A-G-E, which is a
comprehensive formulation for enhancing the antioxidant protection. It also
contains nutrients that help support the body to maintain optimum health.

Resveratrol, a polyphenol naturally present in red wine and grapes,
possesses diverse biochemical and physiological properties, including
estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide
range of health benefits ranging from chemoprevention to cardioprotection.
Recently, several studies described resveratrol as an anti-aging compound.
In the journal Heart Failure Review, Das D.K. et al focused on the anti-aging
aspects of resveratrol, the possible mechanisms of action, and emerging
controversy on its life-prolonging ability. It appears that resveratrol can induce
the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1,
Foxo3a and PBEF, and prevent aging-related decline in cardiovascular
function including cholesterol level and inflammatory response, but it is unable
to affect actual survival or life span of mice.
A Chinese study was carried out to research resveratrol's mechanism of
immunity in anti-aging and explore the new clinical use of resveratrol. The sub
acute aging model was made by continuous subcutaneous injection of Dgalactose
to mice inducing reactive oxygen species. Meanwhile, resveratrol
was given and its effect on anti-aging was observed.
Resveratrol could increase the content of SOD and decrease the content of
MDA in serum. There was no change in spleen index, but thymus index
increased obviously. There was no change in the quantity of CD4+, but the
quantity of CD8+ increased and the ratio of CD4+/CD8+ was decreased. The
serum IL-6 and IL-8 level were decreased obviously. The study showed that
resveratrol possessed the function to anti-aging and the applications
foreground in anti-aging.

Grape Seed contains a high level of proanthocyanidins, also known as OPCs,
which belong to the flavonoid family. OPCs have antioxidant activity and they
play a role in the stabilization of collagen and maintenance of elastin. These
two proteins are found in connective tissues that support organs, joints, blood
vessels and muscle. OPCs have been shown to strengthen capillaries,
improve aspects of vision, and prevent abnormal blood clotting in smokers.
Indian researchers studied the modulatory role of OPCs rich grape seed
extract (GSP) on membrane surface charge density in red blood cells of
animals with age-associated oxidative stress. Young and aged rats were
administered with GSP orally for 15 and 30 days.
When comparing the red blood cells of aged rats with young rat, there was a
significant decrease in surface charge levels with concomitant increase in
protein carbonyls, and decrease in glycoprotein and antioxidants status. The
supplementation of GSP increased the red blood cell surface charge density
to near normalcy in aged rats, decreased protein carbonyls level, and
increased glycoproteins and antioxidant status in the red blood cells of the
aged rats. The researchers therefore concluded that GSP was an effective
anti-aging supplement in preventing the oxidative stress associated loss of
membrane surface charge, which thereby maintains the red blood cell
membrane integrity and functions in elderly.
The same group of researchers also evaluated the role of GSP on lipid
peroxidation and antioxidant status in discrete regions of the central nervous
system of young and aged rats. The aged rats showed age-associated
increase in lipid peroxidation in the spinal cord, cerebral cortex, striatum and
the hippocampus regions. When comparing the aged rats to young rats,
activities of antioxidant enzymes and levels of non-enzymic antioxidants were
found to be significantly decreased in all the brain regions. Normalized lipid
peroxidation and antioxidant defenses were reported in the GSPsupplemented
aged rats. These findings demonstrated that GSP enhanced
the antioxidant status and decreased the incidence of free radical-induced
lipid peroxidation in the central nervous system of aged rats. Both these studies show the importance of GSP in aged individuals by
maintaining the red blood cell membrane integrity and functions, enhancing
the antioxidant status and protecting against lipid peroxidation.

Mucuna pruriens, commonly known as velvet bean or cowitch, is recognized
to enhance mental alertness and improve coordination. It has been shown to
aid in deposition of protein in the muscles and increased muscle mass and
strength. Mucuna pruriens has long been used in traditional Ayurvedic Indian
medicine for diseases including Parkinson’s disease, which occurs primarily in
the elderly, resulting from progressive damage to the nerves in the area of the
brain responsible for controlling muscle tone and movement.
A randomised, controlled, double blind, crossover trial was carried out to
assess the clinical effects of mucuna in patients with Parkinson's disease and
compare it with standard L-dopa/carbidopa (LD/CD). Compared with standard
LD/CD, the mucuna preparation led to a considerably faster onset of effect,
longer mean on time and higher peak L-dopa plasma concentrations. The
findings suggest that mucuna, natural source of L-dopa, might possess
advantages over conventional L-dopa preparations in the long-term
management of Parkinson’s disease.
Mucuna was also studied to investigate its antioxidant property in vitro using
rat liver homogenate. Mucuna significantly inhibited FeSO(4) induced lipid
peroxidation and the specific chemical reactions induced by superoxides and
hydroxyl radicals. It could be concluded that mucuna possesses an anti-lipid
peroxidation property.

Ginkgo Biloba is one of the world’s oldest living tree species. It has many
valuable effects in human body including stabilising cell membranes, reducing
free radical damage, improving blood circulation and enhancing oxygen and
glucose use. Ginkgo is particularly beneficial for brain, nerves and blood
vessels. It has been used in senile conditions including Alzheimer’s disease,
hardening of the arteries, depression and allergies, and oxygen deprivation.
An animal study was undertaken to evaluate the pharmacological effects of
ginkgo on aging. It was found that ginkgo extended the animals’ median life
span, and increased resistance to acute oxidative and thermal stress. Hence
ginkgo may play an important role on aging and counteract the oxidative
stress, which is a major determinant of life span.

Milk Thistle, which is native to Europe and some part of the USA, has been
well known for its powerful liver-protecting properties. It aids in preventing the
damage and improving the function of liver. It has been used widely in liver
disease, including cirrhosis and hepatitis, gallstones and psoriasis.
Silymarin, a flavonoid isolated from milk thistle, has been studied in vitro and
in vivo effects on the expression and activity of superoxide dismutase (SOD)
enzyme and on certain cellular immune reactions in lymphocytes from
cirrhotic patients and from healthy control subjects. The results suggest that
silymarin possesses both antioxidant and immunomodulatory activities that
might be important factors in the hepato-protective action.

Bacopa Monniera is native to India and has been used in Ayurvedic
medicine as a diuretic and as a tonic for the nervous system and the heart. It
has been used for asthma, insanity and epilepsy. It has been found to
enhance several aspects of mental function and learning ability, reduce
anxiety and depression, enhance the effects of neurotransmitters, exert
antioxidant activity in the brain, and relax the muscles.
In Italy, Russo et al studied the free radical scavenging capacity and
protective effect of Bacopa monniera on DNA damage. The result showed a
significant protective effect on H2O2-induced cytoxicity and DNA damage in
human non-immortalized fibroblasts. This study suggests that because of its
antioxidant activity, Bacopa monniera may be useful for human pathologies in
which free radical production plays a key role. The antioxidant capacity of
Bacopa monniera may explain the reported anti-stress, immunomodulatory,
cognition-facilitating, anti-inflammatory and anti-aging effects produced in
experimental animals and in clinical situations.

Goji is well known for nourishing the liver, and in turn, improving the eyesight.
However, many people have forgotten its anti-aging properties. Valuable
components of goji are not limited to its coloured components containing
zeaxanthin and carotene, but include the polysaccharides and small
molecules such as betaine, cerebroside, beta-sitosterol, p-coumaric, and
various vitamins. Despite the fact that goji has been used for centuries, its
beneficial effects to our bodies have not been comprehensively studied with
modern technology to unravel its therapeutic effects at the biochemical level.
Recently, the laboratory at The University of Hong Kong has demonstrated its
neuroprotective effects to counter neuronal loss in neurodegenerative
diseases. Polysaccharides extracted from goji can protect neurons against
beta-amyloid peptide toxicity in neuronal cell cultures, and retinal ganglion
cells in an experimental model of glaucoma. The researchers have
accumulated scientific evidence for its anti-aging effects that should be
highlighted for modern preventive medicine.

Acai is a rainforest berry that grows in the Amazon basin. This dark purple
berry has a fruity taste with a hint of chocolate. For centuries the local
inhabitants have used the berry as a staple part of their diet to boost energy
levels, build the immune system and treat ailments including infections and
diarrhoea. With high levels of antioxidants and cholesterol-fighting fatty acids,
acai has been hailed as the new 'superfood'. It is a rich source of a class of
polyphenolic flavonoids called anthocyanins, which are the same antioxidants
that give wine its health benefits. Antioxidants are needed by the body to
quench free radicals, whose oxidative damage contributes to aging and
degenerative diseases.
Superoxide dismutase 1 (SOD1), a critical enzyme against oxidative stress, is
implicated in aging and degenerative diseases. The effect of acai
supplementation was investigated at the early or late young adulthood on
lifespan, physiological function, and oxidative damage in sod1 knockdown
flies. It was found that acai supplementation extended lifespan even when
started at the age of 10 days, which is the time shortly before the mortality
rate of flies accelerated. Life-long acai supplementation increased lifetime
reproductive output in sod1 knockdown flies. The molecular studies indicate
that acai supplementation reduced the protein levels of genes involved in
oxidative stress response, cellular growth, and nutrient metabolism. Acai
supplementation also affected the protein levels of ribosomal proteins. In
addition, acai supplementation decreased the transcript levels of genes
involved in oxidative stress response and gluconeogenesis, while increasing
the transcript levels of mitochondrial biogenesis genes.
The findings suggest that acai supplementation promotes healthy aging in
sod1-deficient flies partly through reducing oxidative damage, and modulating
nutrient metabolism and oxidative stress response pathways. These findings
provide a foundation to further evaluate the viability of using acai as an
effective dietary intervention to promote healthy aging and alleviate symptoms
of diseases with a high level of oxidative stress.
Aging is a multi-factorial process, which involves deprivation in body's
metabolism. Brain mitochondria are prone to oxidative damage owing to their
high metabolic rate. The decline in antioxidant system during aging augments
the neuronal damage to mitochondrial components like antioxidant system,
Kreb's cycle enzymes and electron transport chain complexes. Since brain is
an organ rich in fatty acids, lipid peroxidation products like hydroxynonenal
are predominant. Those lipid peroxidation products conjugate with amino
acids to form adducts which alter their structural and functional properties.

Green Tea contains a potent antioxidant, Epigallo catechin gallate (EGCG). A
study elucidated the antioxidant potential of EGCG to counteract the
mitochondrial oxidative damage in brain. The study comprised of young and
aged male albino rats of Wistar strain in Groups I and II. Groups III and IV
comprised of young and aged rats supplemented with EGCG for 30 days.
Antioxidants, Kreb's cycle enzymes and electron transport chain complexes
were assayed in the mitochondrial fraction. Hydroxynonenal expression was
carried out using immunohistochemical analysis.
EGCG supplementation decreased the expression of hydroxynonenal in aged
brain, up-regulated the antioxidant system and augmented the activities of
Kreb's cycle enzymes and electron transport chain complexes in aged brain
mitochondria thus proving its antioxidant potential at the level of mitochondria.
The results demonstrated that EGCG in Green Tea has a promising role in
aging animals, and possibly in aging humans as well.

Tumeric is a member of the ginger family and is a commonly used curry
spice. It has antioxidant, anti-inflammatory, carminative and cholesterolAnti
lowering effects. It is beneficial for the digestive system and useful in
inflammatory conditions. Tumeric has been used to prevent cardiovascular
disease and cancer.
Curcumin is the phenolic compound and the yellow pigment in tumeric. A US
review has found curcumin to have favourable safety profiles, epidemiology
and efficacy, and may exert general anti-aging benefits which include anticancer
and cardio-protective.

L-Arginine Pyroglutamate is found in dairy, meat, poultry, fish, nuts and
chocolate. It has several roles in the body, such as assisting in wound
healing, helping remove excess ammonia from the body, stimulating immune
function, and promoting secretion of several hormones including insulin and
growth hormone. Arginine is needed to increase protein synthesis, which in
turn increase cellular replication. It also appears to act as a natural blood
thinner by reducing platelet aggregation.
The effect of arginine on endothelial aging was investigated by German
researchers. Asymmetric dimethylarginine (ADMA) and homocysteine
accelerated the process of aging and inhibited significantly the population
doublings. The outcome of the study demonstrates that arginine prevents the
onset of endothelial aging in ADMA or homocysteine-treated cells by
increasing nitric oxide formation and reducing oxidative stress. Hence arginine
may play a role in preventing cell aging.

Collagen is a group of naturally occurring proteins found in animals,
especially in the flesh and connective tissues of vertebrates. It is the main
component of connective tissue, and is the most abundant protein in
mammals, making up about 25% to 35% of the whole-body protein content.
Collagen is mostly found in fibrous tissues such as tendon, ligament and skin,
and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and
intervertebral disc.
In Brazil, the effect of daily ingestion of collagen hydrolysate (CH) on skin
extracellular matrix proteins was investigated. Four-week-old male Wistar rats
were fed a modified AIN-93 diet containing 12% casein as the reference
group or CH as the treatment group. A control group was established in which
animals were fed a non-protein-modified AIN-93 diet. The diets were
administered continuously for 4 weeks when six fresh skin samples from each
group were assembled and subjected to extraction of protein. Type I and IV
collagens were studied by immunoblot, and activities of matrix
metalloproteinase (MMP) 2 and 9 were assessed by zymography.
The relative amounts of type I and IV collagens was significantly increased
after CH intake compared with the reference diet group (casein). Moreover,
CH uptake significantly decreased both proenzyme and active forms of MMP2
compared with casein and control groups. In contrast, CH ingestion did not
influence on MMP9 activity. These results suggest that CH may reduce aging
related changes of the extracellular matrix by stimulating anabolic processes
in skin tissue.

L-Glutamine is the most abundant amino acid in the body and is involved in
more metabolic processes than any other amino acid. It is converted to
glucose when more glucose is required by the body as an energy source. It
serves as a source of fuel for cells lining the intestines. Glutamine is also used
by white blood cells and is important for immune function. Animal studies
have shown glutamine to possess anti-inflammatory effects.
Antuono PG et al from Department of Neurology at Medical College of
Wisconsin in US evaluated whether glutamate + glutamine (GLX) levels in the
brain distinguish between probable Alzheimer's disease and normal aging.
The results indicate that glutamate + glutamine reduction may be a biologic
marker for Alzheimer’s disease and may be a potential aid in the early clinical
diagnosis of Alzheimer’s disease.

Deer Velvet has been used for centuries in Asia, Russia and New Zealand for
a range of health benefits. It contains both male and female hormones,
cartilage components, enzymes, minerals, vitamins, and prostaglandins. Deer
velvet has been used to aid in controlling blood pressure, increasing
haemoglobin levels, increasing lung efficiency, improving muscle tone and
glandular functions, sharpening mental alertness, relieving inflammation of
arthritis and healing stomach ulcers.
In young individuals, the concentration of human growth hormone is relatively
healthy. As the age increases, the growth hormone level decreases along with
IGF-1 (Insulin-like Growth Factor-1), which causes muscular atrophy. Deer
velvet contains IGF-1, a natural source of growth factor that helps to improve
cell growth and muscular development.

L-Lysine is an essential amino acid needed for growth and helps to maintain
nitrogen balance in the body. It appears to help the body absorb and conserve
calcium. It is incorporated into many proteins and is used by the body for a
variety of purposes including interfere with the replication of herpes viruses
that are associated with cold sores or genital herpes.

Acetyl-L-Carnitine is a vitamin-like compound with a structure similar to an
amino acid. It is found in food, particularly in meat and dairy products, and can
be made by the body from the amino acid, lysine. It is essential for fat
metabolism as it transports fatty acids into the mitochondria, where they are
burned to release energy for body functions. Thus, carnitine increases the use
of fat as an energy source. It has been used in several types of cardiovascular
disease and Alzheimer’s disease.
In Italy, researchers studied the effect of acetyl-L-carnitine in the treatment of
Alzheimer's type senile dementia impairment in a controlled double-blind
study. Thirty patients, aged over 65 years and suffering from mild mental
impairment, were randomly divided into two group with one group underwent
acetyl-L-carnitine supplementation for three months, while the other group
was given with a placebo.
The results showed that the acetyl-L-carnitine supplemented patients showed
statistically significant improvement in the behavioural scales, in the memory
tests, in the attention barrage test and in the Verbal Fluency test. These
satisfactory findings confirm the beneficial importance of acetyl-L-carnitine in
the treatment of elderly patients with mental impairment.

L-Ornithine is an amino acid manufactured by the body and is found
predominantly in meat, fish, dairy and eggs. It has been suggested to promote
muscle-building by increasing the levels of growth-promoting hormones when
taken along with arginine. It has beneficial effects for people hospitalized for
surgery, generalized infections, cancer, trauma or burns. Ornithine also helps
to improve wound healing and liver function.
Specific amino acids, such as arginine, lysine and ornithine, are often used by
athletes to stimulate growth hormone release. An animal study reports these
basic amino acids mainly decreased in level with aging. Hence it is beneficial
for aged individuals to supplement these amino acids to aid with the
stimulation of growth hormone release.

L-Carnosine is a small molecule composed of the amino acids, histidine and
alanine. It is found in relatively high concentrations in several body tissues
including skeletal muscle, heart muscle and brain, as well as lens. Studies
have demonstrated that it possesses strong and specific antioxidant
properties, protects against radiation damage, improves the function of the
heart, and promotes wound healing. Carnosine is also involved in actions as a
neurotransmitter, modulator of enzyme activities and heavy metals chelator.
A group of UK researchers studied the pluripotent (capable of affecting more
than one organ or tissue) protective effects of carnosine. In 1994, it was
shown that carnosine could delay senescence of cultured human fibroblasts,
cells that contribute to the formation of connective tissue fibres. In addition to
antioxidant and oxygen free-radical scavenging activities, carnosine also
reacts with deleterious aldehydes to protect susceptible macromolecules.
Their studies show that carnosine inhibits non-enzymatic glycosylation and
cross-linking of proteins induced by reactive aldehydes in vitro. Additionally
carnosine was found to inhibit formation of advanced glycosylation end
products (AGEs) and formation of DNA-protein cross-links. It was proposed
that carnosine might be beneficial for intervention in pathologies that involved
deleterious aldehydes, for example, secondary diabetic complications,
inflammatory phenomena, alcoholic liver disease, and Alzheimer’s disease.

Ascorbic Acid (Vitamin C) is a water-soluble vitamin that is involved in
hundreds of vital biological processes in the body. These include wound
healing, healthy immune and nervous systems, adrenal hormone production
and act as antioxidant. Vitamin C is also essential for the manufacture of
collagen, a protein that forms the basis of connective tissues such as bones,
teeth and cartilage.
Oxidative stress produced by aerobic metabolism has been shown to
accelerate cellular senescence. In Japan, researchers demonstrated that
ascorbic acid decreased the level of oxidative stress and extended the
replicative life span. Therefore ascorbic acid helps to fight against oxidative
free radical damage, which is associated with aging.

Coenzyme Q10, which is also known as ubiquinone, is one form of a
substance known as coenzyme Q that is found in all plant and animal cells. It
is essential for energy production and ATP formation. Coenzyme Q10 is an
antioxidant that protects against free radical damage to cell structures and
other substances in the body. It works together with vitamin E and may
protect vitamin E from damage.
Oxidative stress induces structural and functional changes in red blood cells.
Coenzyme Q10 is known as a compound, which may partially prevent those
changes in red blood cells, due to its antioxidative properties. The content of
the coenzyme in human body decreases with age.
A research was undertaken in Poland to evaluate the influence of coenzyme
Q10 on structural and functional parameters of red blood cells in elderly
people. The examination was performed on 35 elderly people that were older
than 65 years old. After three and six weeks of coenzyme Q10
supplementation in elderly people, a decrease of lipid peroxidation products
and internal micro-viscosity of red blood cells, and an increase of the activity
of membrane ATP-ase were observed. The results may indicate the
intensification of oxidative stress in elderly and point to beneficial effect of
coenzyme Q10 supplementation on structural and functional parameters of
red blood cells in elderly people.

Phosphatidyl Serine (PS) belongs to a category of fat-soluble substances
called phospholipids, which are essential components of cell membranes. It is
found in high concentrations in the brain. Adults age 50 and older, especially
those with age-related cognitive decline, may not synthesize enough PS, and
appear most likely to benefit from supplemental PS.
A double-blind study was undertaken to assess the efficacy and the safety of
PS supplementation for 6 months in a group of geriatric patients with cognitive
impairment. A total of 494 elderly patients with moderate to severe cognitive
decline, were recruited in 23 Geriatric or General Medicine Units in Northeastern
Italy. Patients were examined before starting the study, and 3 and 6
months thereafter. The efficacy of PS compared to placebo was measured on
the basis of changes occurring in behaviour and cognitive performance using
Plutchik Geriatric Rating Scale and Buschke Selective Reminding Test.
Statistically significant improvements in the PS group compared to placebo
were observed both in terms of behavioural and cognitive parameters. In

addition, clinical evaluation and laboratory tests demonstrated that PS was
well tolerated. These results suggest PS may be a promising candidate for the
geriatric patients with cognitive impairment.

d-Alpha Tocopherol (Vitamin E) is an antioxidant that protects cell
membranes and other fat-soluble parts of the body from damage. It is also
known to act through other mechanisms including direct effects on
inflammation, blood cell regulation, connective tissue growth and genetic
control of cell division.
Oxidative stress has been implicated in dementia, a common cognitive
syndrome reflecting a wide spread chronic progressive disease as an
extension to normal aging process. The antioxidants have become attractive
therapeutic agents. Among the antioxidants, vitamin E is the most potent in
the treatment of dementia.
An Indian study was conducted to examine the role of vitamin E in patients
suffering from dementia in the age group of 66-74 and in age and sex
matched controls. The result demonstrates that vitamin E supplementation
decreased the latency and increased the P3 amplitude in both the control and
dementia patients. This finding supports that Vitamin E, because of its
antioxidant property might be decreasing oxidative stress, which may lead to
improvement in cognitive pool.

Alpha Lipoic Acid is a fat-soluble compound produced in the body and is
found in some foods such as liver and yeast. It plays an important role in the
breakdown of carbohydrates, fats and protein. It is also an antioxidant,
effective against both water and fat-soluble free radicals. Alpha lipoic acid
may combine with free iron and copper in the body and protect against the
oxidative damage exerted by these free ions.
The effect of alpha lipoic acid on lipid peroxidation and antioxidant enzymes
were evaluated in various brain regions of young and aged rats. Alpha lipoic
acid administered aged rats showed a duration dependent reduction in the
level of lipid peroxidation and elevation in the activities of antioxidant
enzymes. There was a rise in the level of alpha lipoic acid in aged rats after
supplementation of alpha lipoic acid in all the brain regions examined.
The results suggest that alpha lipoic acid has a beneficial effect in both
preventing and reversing abnormalities in aging brain. This beneficial effect
was associated with normalization of lipid peroxidation and partial restoration
in the activities of various enzymatic antioxidants suggesting that alpha lipoic
acid supplementation could improve brain antioxidant functions in the elderly.

Piperine is the extract obtained from black pepper. It is a known inhibitor of
hepatic and intestinal glucuronidation. In a study, the effect of combining
piperine was evaluated on the bioavailability of curcumin in rats and healthy
human volunteers. Concomitant administration of piperine produced an
increase in bioavailability of 2000%. The study shows that piperine enhances
the serum concentration, extent of absorption and bioavailability of curcumin
in both rats and humans with no adverse effects. Hence piperine has been
found to aid in improving nutrient absorption.
In summary, Anti A-G-E is a comprehensive formulation containing herbs,
amino acids, vitamins and nutrients for enhancing the antioxidant protection
and contributing to the normal production of growth hormones. The
ingredients also possess cognitive-facilitating, immuno-modulatory, hepatoprotective,
cardio-protective, anti-inflammatory, anti-stress and anti-lipid
peroxidation actions. Anti A-G-E is a useful supplement for males and females
to help support healthy aging.


Antuono P.G., Jones J.L., Wang Y., Li S.J., Decreased glutamate + glutamine
in Alzheimer's disease detected in vivo with (1)H-MRS at 0.5 T, Neurology.
2001 Mar 27; 56 (6): 737-42.
Arivazhagan P., Shila S., Kumaran S., Panneerselvam C., Effect of DL-alphalipoic
acid on the status of lipid peroxidation and antioxidant enzymes in
various brain regions of aged rats, Exp Gerontol. 2002 Jun; 37 (6): 803-11.
Balu M., Sangeetha P., Haripriya D., Panneerselvam C., Rejuvenation of
antioxidant system in central nervous system of aged rats by grape seed
extract, Neurosci Lett. 2005 Aug 5; 383 (3): 295-300.
Banay-Schwartz M., Lajtha A., Palkovits M., Changes with aging in the levels
of amino acids in rat CNS structural elements: IV. Methionine and basic amino
acids, J Neurosci Res. 1990 Jun; 26 (2): 217-23.
Cenacchi T., Bertoldin T., Farina C., Fiori M.G., Crepaldi G., Cognitive decline
in the elderly: a double-blind, placebo-controlled multicenter study on efficacy
of phosphatidylserine administration, Aging (Milano). 1993 Apr; 5 (2): 123-33.
Chromiak J.A., Antonio J., Use of amino acids as growth hormone-releasing
agents by athletes, Nutrition. 2002 Jul-Aug; 18 (7-8): 657-61.
Chang R.C., So K.F., Use of anti-aging herbal medicine, Lycium barbarum,
against aging-associated diseases. What do we know so far? Cell Mol
Neurobiol. 2008 Aug; 28 (5): 643-52.
Cole G.M., Lim G.P., Yang F., Teter B., Begum A., Ma Q., Harris-White M.E.,
Frautschy S.A., Prevention of Alzheimer's disease: Omega-3 fatty acid and
phenolic anti-oxidant interventions, Neurobiol Aging. 2005 Dec; 26 Suppl 1:
133-6. Epub 2005 Nov 2.
Das D.K., Mukherjee S., Ray D., Resveratrol and red wine, healthy heart and
longevity. Heart Fail Rev. 2010 Sep; 15 (5): 467-77.
Duarte A., Abdo J., Velvet deer antler: The 2000-year-old medicine, LE
Feher J., Lang I., Deak G., Cornides A., Nekam K., Gergely P., Free radicals
in tissue damage in liver diseases and therapeutic approach, Tokai J Exp Clin
Med. 1986; 11 Suppl: 121-34.
GNC Healthnotes:
Goraca A., Assessment of total antioxidant capacity in human plasma, Folia
Med (Plovdiv). 2004; 46 (4): 16-21.
Hipkiss A.R., Preston J.E., Himsworth D.T., Worthington V.C., Keown M.,
Michaelis J., Lawrence J., Mateen A., Allende L., Eagles PA., Abbott NJ.,
Pluripotent protective effects of carnosine, a naturally occurring dipeptide, Ann
N Y Acad Sci. 1998 Nov 20; 854: 37-53.
Kashino G., Kodama S., Nakayama Y., Suzuki K., Fukase K., Goto M.,
Watanabe M., Relief of oxidative stress by ascorbic acid delays cellular
senescence of normal human and Werner syndrome fibroblast cells, Free
Radic Biol Med. 2003 Aug 15; 35 (4): 438-43.
Katzenschlager R., Evans A., Manson A., Patsalos P.N., Ratnaraj N., Watt H.,
Timmermann L., Van der Giessen R., Lees A.J., Mucuna pruriens in
Parkinson's disease: a double blind clinical and pharmacological study, J
Neurol Neurosurg Psychiatry. 2004 Dec; 75 (12): 1672-7.
Kedziora-Kornatowska K., Kujawski K., Blaszczak R., Rysz J., Markuszewsk
L., Koter M., Duchnowicz P., Kornatowski T., Olszewski R., Kedziora J., The
influence of Q10 coenzyme on structural and functional parameters of red
blood cells in elderly people, Pol Merkuriusz Lek. 2006 Jan; 20 (115): 57-61.
Laslo M., Sun X., Hsiao C.T., Wu W.W., Shen R.F., Zou S., A botanical
containing freeze dried açai pulp promotes healthy aging and reduces
oxidative damage in sod1 knockdown flies. Age (Dordr). 2012 May 26.
Lelbach A., Feher J., Szekacs B., The molecular biology of aging--therapeutic
interventions? Orv Hetil. 2006 Mar 12; 147 (10): 441-8.
Passeri M., Cucinotta D., Bonati P.A., Iannuccelli M., Parnetti L., Senin U.,
Acetyl-L-carnitine in the treatment of mildly demented elderly patients, Int J
Clin Pharmacol Res. 1990; 10 (1-2): 75-9.
Reavley N., The New Encyclopedia of Vitamins, Minerals, Supplements and
Herbs, Bookman Press, Melbourne, 1998.
Russo A., Izzo A.A., Borrelli F., Renis M., Vanella A., Free radical scavenging
capacity and protective effect of Bacopa monniera L. on DNA damage,
Phytotherapy Research, 2003 Septmber 11; 17 (8): 870-5.
Sangeetha P., Balu M., Haripriya D., Panneerselvam C., Age associated
changes in erythrocyte membrane surface charge: Modulatory role of grape
seed proanthocyanidins, Exp Gerontol. 2005 Oct; 40 (10): 820-8. Epub 2005
Aug 31.
Scalera F., Martens-Lobenhoffer J., Tager M., Bukowska A., Lendeckel U.,
Bode-Boger S.M., Effect of L-arginine on asymmetric dimethylarginine (ADMA)
or homocysteine-accelerated endothelial cell aging, Biochem Biophys Res
Commun. 2006 Jul 7; 345 (3): 1075-82. Epub 2006 May 11.
Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S.,
Influence of piperine on the pharmacokinetics of curcumin in animals and
human volunteers, Planta Med. 1998 May; 64 (4): 353-6.
Srividhya R., Zarkovic K., Stroser M., Waeg G., Zarkovic N., Kalaiselvi P.,
Mitochondrial alterations in aging rat brain: effective role of (-)-epigallo
catechin gallate. Int J Dev Neurosci. 2009 May; 27 (3): 223-31.
Tripathi Y.B., Upadhyay A.K., Effect of the alcohol extract of the seeds of
Mucuna pruriens on free radicals and oxidative stress in albino rats, Phytother
Res, 2002 Sep; 16 (6): 534-8.
Vaney N., Chouhan S., Bhatia M.S., Tandon OP., Event related evoked
potentials in dementia: role of vitamin E, Indian J Physiol Pharmacol. 2002
Jan; 46 (1): 61-8.
Wu Z., Smith J.V., Paramasivam V., Butko P., Khan I., Cypser J.R., Luo Y.,
Ginkgo biloba extract EGb 761 increases stress resistance and extends life
span of Caenorhabditis elegans, Cell Mol Biol (Noisy-le-grand). 2002 Sep; 48
(6): 725-31.
Yao Y., Tian T., Nan K.J., Research on resveratrol's mechanism of immunity
in anti-aging. Zhong Yao Cai. 2006 May; 29 (5): 464-7.
Zague V., de Freitas V., da Costa Rosa M., de Castro G.Á., Jaeger R.G.,
Machado-Santelli G.M., Collagen hydrolysate intake increases skin collagen
expression and suppresses matrix metalloproteinase 2 activity. J Med Food.
2011 Jun; 14 (6): 618-24.


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