What is Anti A-G-E ?
Aging is a
complex mechanism of progressive and
irreversible processes
occurring to molecules, to cells and to the
whole organism and ending with
death. Genetic factors and the combination
of environmental interactions play
the most important role in its development.
The environmental effects, such
as irradiation, toxic chemicals, metal ions,
and free radicals play a
determinant role in the development of
aging. The mechanism of aging
involves changes in macromolecules caused by
free radicals, non-enzymatic
glycosylation and apoptosis.
Human serum contains many different
antioxidants that may be important in
the maintenance of antioxidant protection.
Aging decreases the level of
enzymatic and non-enzymatic antioxidants in
plasma. Goraca A. from Institute
of Physiological and Biochemistry in Poland
investigated the total antioxidant
capacity in plasma obtained from healthy
young and old volunteers in a study
using the ferric reducing antioxidant
capacity.
It was found that the total antioxidant
capacity of plasma obtained from
healthy young females and males did not
differ significantly between each
other and was significantly higher than
plasma antioxidant capacity of elderly
volunteers. The results confirmed that
plasma antioxidant capacity declines
with the volunteers' age and supplementation
of antioxidants could be useful
for enhancement of antioxidant protection in
plasma.
Pro-life has developed an innovative
product, Anti A-G-E, which is a
comprehensive formulation for enhancing the
antioxidant protection. It also
contains nutrients that help support the
body to maintain optimum health.
Resveratrol, a polyphenol naturally
present in red wine and grapes,
possesses diverse biochemical and
physiological properties, including
estrogenic, antiplatelet, and
anti-inflammatory properties as well as a
wide
range of health benefits ranging from
chemoprevention to cardioprotection.
Recently, several studies described
resveratrol as an anti-aging compound.
In the journal Heart Failure Review, Das D.K.
et al focused on the anti-aging
aspects of resveratrol, the possible
mechanisms of action, and emerging
controversy on its life-prolonging ability.
It appears that resveratrol can induce
the expression of several longevity genes
including Sirt1, Sirt3, Sirt4, FoxO1,
Foxo3a and PBEF, and prevent aging-related
decline in cardiovascular
function including cholesterol level and
inflammatory response, but it is unable
to affect actual survival or life span of
mice.
A Chinese study was carried out to research
resveratrol's mechanism of
immunity in anti-aging and explore the new
clinical use of resveratrol. The sub
acute aging model was made by continuous
subcutaneous injection of Dgalactose
to mice inducing reactive oxygen species.
Meanwhile, resveratrol
was given and its effect on anti-aging was
observed.
Resveratrol could increase the content of
SOD and decrease the content of
MDA in serum. There was no change in spleen
index, but thymus index
increased obviously. There was no change in
the quantity of CD4+, but the
quantity of CD8+ increased and the ratio of
CD4+/CD8+ was decreased. The
serum IL-6 and IL-8 level were decreased
obviously. The study showed that
resveratrol possessed the function to
anti-aging and the applications
foreground in anti-aging.
Grape Seed contains a high level of
proanthocyanidins, also known as OPCs,
which belong to the flavonoid family. OPCs
have antioxidant activity and they
play a role in the stabilization of collagen
and maintenance of elastin. These
two proteins are found in connective tissues
that support organs, joints, blood
vessels and muscle. OPCs have been shown to
strengthen capillaries,
improve aspects of vision, and prevent
abnormal blood clotting in smokers.
Indian researchers studied the modulatory
role of OPCs rich grape seed
extract (GSP) on membrane surface charge
density in red blood cells of
animals with age-associated oxidative
stress. Young and aged rats were
administered with GSP orally for 15 and 30
days.
When comparing the red blood cells of aged
rats with young rat, there was a
significant decrease in surface charge
levels with concomitant increase in
protein carbonyls, and decrease in
glycoprotein and antioxidants status. The
supplementation of GSP increased the red
blood cell surface charge density
to near normalcy in aged rats, decreased
protein carbonyls level, and
increased glycoproteins and antioxidant
status in the red blood cells of the
aged rats. The researchers therefore
concluded that GSP was an effective
anti-aging supplement in preventing the
oxidative stress associated loss of
membrane surface charge, which thereby
maintains the red blood cell
membrane integrity and functions in elderly.
The same group of researchers also evaluated
the role of GSP on lipid
peroxidation and antioxidant status in
discrete regions of the central nervous
system of young and aged rats. The aged rats
showed age-associated
increase in lipid peroxidation in the spinal
cord, cerebral cortex, striatum and
the hippocampus regions. When comparing the
aged rats to young rats,
activities of antioxidant enzymes and levels
of non-enzymic antioxidants were
found to be significantly decreased in all
the brain regions. Normalized lipid
peroxidation and antioxidant defenses were
reported in the GSPsupplemented
aged rats. These findings demonstrated that
GSP enhanced
the antioxidant status and decreased the
incidence of free radical-induced
lipid peroxidation in the central nervous
system of aged rats. Both these studies show
the importance of GSP in aged individuals by
maintaining the red blood cell membrane
integrity and functions, enhancing
the antioxidant status and protecting
against lipid peroxidation.
Mucuna pruriens, commonly known as
velvet bean or cowitch, is recognized
to enhance mental alertness and improve
coordination. It has been shown to
aid in deposition of protein in the muscles
and increased muscle mass and
strength. Mucuna pruriens has long been used
in traditional Ayurvedic Indian
medicine for diseases including Parkinson’s
disease, which occurs primarily in
the elderly, resulting from progressive
damage to the nerves in the area of the
brain responsible for controlling muscle
tone and movement.
A randomised, controlled, double blind,
crossover trial was carried out to
assess the clinical effects of mucuna in
patients with Parkinson's disease and
compare it with standard L-dopa/carbidopa
(LD/CD). Compared with standard
LD/CD, the mucuna preparation led to a
considerably faster onset of effect,
longer mean on time and higher peak L-dopa
plasma concentrations. The
findings suggest that mucuna, natural source
of L-dopa, might possess
advantages over conventional L-dopa
preparations in the long-term
management of Parkinson’s disease.
Mucuna was also studied to investigate its
antioxidant property in vitro using
rat liver homogenate. Mucuna significantly
inhibited FeSO(4) induced lipid
peroxidation and the specific chemical
reactions induced by superoxides and
hydroxyl radicals. It could be concluded
that mucuna possesses an anti-lipid
peroxidation property.
Ginkgo Biloba is one of the world’s
oldest living tree species. It has many
valuable effects in human body including
stabilising cell membranes, reducing
free radical damage, improving blood
circulation and enhancing oxygen and
glucose use. Ginkgo is particularly
beneficial for brain, nerves and blood
vessels. It has been used in senile
conditions including Alzheimer’s disease,
hardening of the arteries, depression and
allergies, and oxygen deprivation.
An animal study was undertaken to evaluate
the pharmacological effects of
ginkgo on aging. It was found that ginkgo
extended the animals’ median life
span, and increased resistance to acute
oxidative and thermal stress. Hence
ginkgo may play an important role on aging
and counteract the oxidative
stress, which is a major determinant of life
span.
Milk Thistle, which is native to
Europe and some part of the USA, has been
well known for its powerful liver-protecting
properties. It aids in preventing the
damage and improving the function of liver.
It has been used widely in liver
disease, including cirrhosis and hepatitis,
gallstones and psoriasis.
Silymarin, a flavonoid isolated from milk
thistle, has been studied in vitro and
in vivo effects on the expression and
activity of superoxide dismutase (SOD)
enzyme and on certain cellular immune
reactions in lymphocytes from
cirrhotic patients and from healthy control
subjects. The results suggest that
silymarin possesses both antioxidant and
immunomodulatory activities that
might be important factors in the hepato-protective
action.
Bacopa Monniera is native to India
and has been used in Ayurvedic
medicine as a diuretic and as a tonic for
the nervous system and the heart. It
has been used for asthma, insanity and
epilepsy. It has been found to
enhance several aspects of mental function
and learning ability, reduce
anxiety and depression, enhance the effects
of neurotransmitters, exert
antioxidant activity in the brain, and relax
the muscles.
In Italy, Russo et al studied the free
radical scavenging capacity and
protective effect of Bacopa monniera on DNA
damage. The result showed a
significant protective effect on
H2O2-induced cytoxicity and DNA damage in
human non-immortalized fibroblasts. This
study suggests that because of its
antioxidant activity, Bacopa monniera may be
useful for human pathologies in
which free radical production plays a key
role. The antioxidant capacity of
Bacopa monniera may explain the reported
anti-stress, immunomodulatory,
cognition-facilitating, anti-inflammatory
and anti-aging effects produced in
experimental animals and in clinical
situations.
Goji is well known for nourishing the
liver, and in turn, improving the eyesight.
However, many people have forgotten its
anti-aging properties. Valuable
components of goji are not limited to its
coloured components containing
zeaxanthin and carotene, but include the
polysaccharides and small
molecules such as betaine, cerebroside,
beta-sitosterol, p-coumaric, and
various vitamins. Despite the fact that goji
has been used for centuries, its
beneficial effects to our bodies have not
been comprehensively studied with
modern technology to unravel its therapeutic
effects at the biochemical level.
Recently, the laboratory at The University
of Hong Kong has demonstrated its
neuroprotective effects to counter neuronal
loss in neurodegenerative
diseases. Polysaccharides extracted from
goji can protect neurons against
beta-amyloid peptide toxicity in neuronal
cell cultures, and retinal ganglion
cells in an experimental model of glaucoma.
The researchers have
accumulated scientific evidence for its
anti-aging effects that should be
highlighted for modern preventive medicine.
Acai is a rainforest berry that grows
in the Amazon basin. This dark purple
berry has a fruity taste with a hint of
chocolate. For centuries the local
inhabitants have used the berry as a staple
part of their diet to boost energy
levels, build the immune system and treat
ailments including infections and
diarrhoea. With high levels of antioxidants
and cholesterol-fighting fatty acids,
acai has been hailed as the new 'superfood'.
It is a rich source of a class of
polyphenolic flavonoids called anthocyanins,
which are the same antioxidants
that give wine its health benefits.
Antioxidants are needed by the body to
quench free radicals, whose oxidative damage
contributes to aging and
degenerative diseases.
Superoxide dismutase 1 (SOD1), a critical
enzyme against oxidative stress, is
implicated in aging and degenerative
diseases. The effect of acai
supplementation was investigated at the
early or late young adulthood on
lifespan, physiological function, and
oxidative damage in sod1 knockdown
flies. It was found that acai
supplementation extended lifespan even when
started at the age of 10 days, which is the
time shortly before the mortality
rate of flies accelerated. Life-long acai
supplementation increased lifetime
reproductive output in sod1 knockdown flies.
The molecular studies indicate
that acai supplementation reduced the
protein levels of genes involved in
oxidative stress response, cellular growth,
and nutrient metabolism. Acai
supplementation also affected the protein
levels of ribosomal proteins. In
addition, acai supplementation decreased the
transcript levels of genes
involved in oxidative stress response and
gluconeogenesis, while increasing
the transcript levels of mitochondrial
biogenesis genes.
The findings suggest that acai
supplementation promotes healthy aging in
sod1-deficient flies partly through reducing
oxidative damage, and modulating
nutrient metabolism and oxidative stress
response pathways. These findings
provide a foundation to further evaluate the
viability of using acai as an
effective dietary intervention to promote
healthy aging and alleviate symptoms
of diseases with a high level of oxidative
stress.
Aging is a multi-factorial process, which
involves deprivation in body's
metabolism. Brain mitochondria are prone to
oxidative damage owing to their
high metabolic rate. The decline in
antioxidant system during aging augments
the neuronal damage to mitochondrial
components like antioxidant system,
Kreb's cycle enzymes and electron transport
chain complexes. Since brain is
an organ rich in fatty acids, lipid
peroxidation products like hydroxynonenal
are predominant. Those lipid peroxidation
products conjugate with amino
acids to form adducts which alter their
structural and functional properties.
Green Tea contains a potent
antioxidant, Epigallo catechin gallate (EGCG).
A
study elucidated the antioxidant potential
of EGCG to counteract the
mitochondrial oxidative damage in brain. The
study comprised of young and
aged male albino rats of Wistar strain in
Groups I and II. Groups III and IV
comprised of young and aged rats
supplemented with EGCG for 30 days.
Antioxidants, Kreb's cycle enzymes and
electron transport chain complexes
were assayed in the mitochondrial fraction.
Hydroxynonenal expression was
carried out using immunohistochemical
analysis.
EGCG supplementation decreased the
expression of hydroxynonenal in aged
brain, up-regulated the antioxidant system
and augmented the activities of
Kreb's cycle enzymes and electron transport
chain complexes in aged brain
mitochondria thus proving its antioxidant
potential at the level of mitochondria.
The results demonstrated that EGCG in Green
Tea has a promising role in
aging animals, and possibly in aging humans
as well.
Tumeric is a member of the ginger
family and is a commonly used curry
spice. It has antioxidant,
anti-inflammatory, carminative and
cholesterolAnti
lowering effects. It is beneficial for the
digestive system and useful in
inflammatory conditions. Tumeric has been
used to prevent cardiovascular
disease and cancer.
Curcumin is the phenolic compound and the
yellow pigment in tumeric. A US
review has found curcumin to have favourable
safety profiles, epidemiology
and efficacy, and may exert general
anti-aging benefits which include anticancer
and cardio-protective.
L-Arginine Pyroglutamate is found in
dairy, meat, poultry, fish, nuts and
chocolate. It has several roles in the body,
such as assisting in wound
healing, helping remove excess ammonia from
the body, stimulating immune
function, and promoting secretion of several
hormones including insulin and
growth hormone. Arginine is needed to
increase protein synthesis, which in
turn increase cellular replication. It also
appears to act as a natural blood
thinner by reducing platelet aggregation.
The effect of arginine on endothelial aging
was investigated by German
researchers. Asymmetric dimethylarginine (ADMA)
and homocysteine
accelerated the process of aging and
inhibited significantly the population
doublings. The outcome of the study
demonstrates that arginine prevents the
onset of endothelial aging in ADMA or
homocysteine-treated cells by
increasing nitric oxide formation and
reducing oxidative stress. Hence arginine
may play a role in preventing cell aging.
Collagen is a group of naturally
occurring proteins found in animals,
especially in the flesh and connective
tissues of vertebrates. It is the main
component of connective tissue, and is the
most abundant protein in
mammals, making up about 25% to 35% of the
whole-body protein content.
Collagen is mostly found in fibrous tissues
such as tendon, ligament and skin,
and is also abundant in cornea, cartilage,
bone, blood vessels, the gut, and
intervertebral disc.
In Brazil, the effect of daily ingestion of
collagen hydrolysate (CH) on skin
extracellular matrix proteins was
investigated. Four-week-old male Wistar rats
were fed a modified AIN-93 diet containing
12% casein as the reference
group or CH as the treatment group. A
control group was established in which
animals were fed a non-protein-modified
AIN-93 diet. The diets were
administered continuously for 4 weeks when
six fresh skin samples from each
group were assembled and subjected to
extraction of protein. Type I and IV
collagens were studied by immunoblot, and
activities of matrix
metalloproteinase (MMP) 2 and 9 were
assessed by zymography.
The relative amounts of type I and IV
collagens was significantly increased
after CH intake compared with the reference
diet group (casein). Moreover,
CH uptake significantly decreased both
proenzyme and active forms of MMP2
compared with casein and control groups. In
contrast, CH ingestion did not
influence on MMP9 activity. These results
suggest that CH may reduce aging
related changes of the extracellular matrix
by stimulating anabolic processes
in skin tissue.
L-Glutamine is the most abundant
amino acid in the body and is involved in
more metabolic processes than any other
amino acid. It is converted to
glucose when more glucose is required by the
body as an energy source. It
serves as a source of fuel for cells lining
the intestines. Glutamine is also used
by white blood cells and is important for
immune function. Animal studies
have shown glutamine to possess
anti-inflammatory effects.
Antuono PG et al from Department of
Neurology at Medical College of
Wisconsin in US evaluated whether glutamate
+ glutamine (GLX) levels in the
brain distinguish between probable
Alzheimer's disease and normal aging.
The results indicate that glutamate +
glutamine reduction may be a biologic
marker for Alzheimer’s disease and may be a
potential aid in the early clinical
diagnosis of Alzheimer’s disease.
Deer Velvet has been used for
centuries in Asia, Russia and New Zealand
for
a range of health benefits. It contains both
male and female hormones,
cartilage components, enzymes, minerals,
vitamins, and prostaglandins. Deer
velvet has been used to aid in controlling
blood pressure, increasing
haemoglobin levels, increasing lung
efficiency, improving muscle tone and
glandular functions, sharpening mental
alertness, relieving inflammation of
arthritis and healing stomach ulcers.
In young individuals, the concentration of
human growth hormone is relatively
healthy. As the age increases, the growth
hormone level decreases along with
IGF-1 (Insulin-like Growth Factor-1), which
causes muscular atrophy. Deer
velvet contains IGF-1, a natural source of
growth factor that helps to improve
cell growth and muscular development.
L-Lysine is an essential amino acid
needed for growth and helps to maintain
nitrogen balance in the body. It appears to
help the body absorb and conserve
calcium. It is incorporated into many
proteins and is used by the body for a
variety of purposes including interfere with
the replication of herpes viruses
that are associated with cold sores or
genital herpes.
Acetyl-L-Carnitine is a vitamin-like
compound with a structure similar to an
amino acid. It is found in food,
particularly in meat and dairy products, and
can
be made by the body from the amino acid,
lysine. It is essential for fat
metabolism as it transports fatty acids into
the mitochondria, where they are
burned to release energy for body functions.
Thus, carnitine increases the use
of fat as an energy source. It has been used
in several types of cardiovascular
disease and Alzheimer’s disease.
In Italy, researchers studied the effect of
acetyl-L-carnitine in the treatment of
Alzheimer's type senile dementia impairment
in a controlled double-blind
study. Thirty patients, aged over 65 years
and suffering from mild mental
impairment, were randomly divided into two
group with one group underwent
acetyl-L-carnitine supplementation for three
months, while the other group
was given with a placebo.
The results showed that the
acetyl-L-carnitine supplemented patients
showed
statistically significant improvement in the
behavioural scales, in the memory
tests, in the attention barrage test and in
the Verbal Fluency test. These
satisfactory findings confirm the beneficial
importance of acetyl-L-carnitine in
the treatment of elderly patients with
mental impairment.
L-Ornithine is an amino acid
manufactured by the body and is found
predominantly in meat, fish, dairy and eggs.
It has been suggested to promote
muscle-building by increasing the levels of
growth-promoting hormones when
taken along with arginine. It has beneficial
effects for people hospitalized for
surgery, generalized infections, cancer,
trauma or burns. Ornithine also helps
to improve wound healing and liver function.
Specific amino acids, such as arginine,
lysine and ornithine, are often used by
athletes to stimulate growth hormone
release. An animal study reports these
basic amino acids mainly decreased in level
with aging. Hence it is beneficial
for aged individuals to supplement these
amino acids to aid with the
stimulation of growth hormone release.
L-Carnosine is a small molecule
composed of the amino acids, histidine and
alanine. It is found in relatively high
concentrations in several body tissues
including skeletal muscle, heart muscle and
brain, as well as lens. Studies
have demonstrated that it possesses strong
and specific antioxidant
properties, protects against radiation
damage, improves the function of the
heart, and promotes wound healing. Carnosine
is also involved in actions as a
neurotransmitter, modulator of enzyme
activities and heavy metals chelator.
A group of UK researchers studied the
pluripotent (capable of affecting more
than one organ or tissue) protective effects
of carnosine. In 1994, it was
shown that carnosine could delay senescence
of cultured human fibroblasts,
cells that contribute to the formation of
connective tissue fibres. In addition to
antioxidant and oxygen free-radical
scavenging activities, carnosine also
reacts with deleterious aldehydes to protect
susceptible macromolecules.
Their studies show that carnosine inhibits
non-enzymatic glycosylation and
cross-linking of proteins induced by
reactive aldehydes in vitro. Additionally
carnosine was found to inhibit formation of
advanced glycosylation end
products (AGEs) and formation of DNA-protein
cross-links. It was proposed
that carnosine might be beneficial for
intervention in pathologies that involved
deleterious aldehydes, for example,
secondary diabetic complications,
inflammatory phenomena, alcoholic liver
disease, and Alzheimer’s disease.
Ascorbic Acid (Vitamin C) is a
water-soluble vitamin that is involved in
hundreds of vital biological processes in
the body. These include wound
healing, healthy immune and nervous systems,
adrenal hormone production
and act as antioxidant. Vitamin C is also
essential for the manufacture of
collagen, a protein that forms the basis of
connective tissues such as bones,
teeth and cartilage.
Oxidative stress produced by aerobic
metabolism has been shown to
accelerate cellular senescence. In Japan,
researchers demonstrated that
ascorbic acid decreased the level of
oxidative stress and extended the
replicative life span. Therefore ascorbic
acid helps to fight against oxidative
free radical damage, which is associated
with aging.
Coenzyme Q10, which is also known as
ubiquinone, is one form of a
substance known as coenzyme Q that is found
in all plant and animal cells. It
is essential for energy production and ATP
formation. Coenzyme Q10 is an
antioxidant that protects against free
radical damage to cell structures and
other substances in the body. It works
together with vitamin E and may
protect vitamin E from damage.
Oxidative stress induces structural and
functional changes in red blood cells.
Coenzyme Q10 is known as a compound, which
may partially prevent those
changes in red blood cells, due to its
antioxidative properties. The content of
the coenzyme in human body decreases with
age.
A research was undertaken in Poland to
evaluate the influence of coenzyme
Q10 on structural and functional parameters
of red blood cells in elderly
people. The examination was performed on 35
elderly people that were older
than 65 years old. After three and six weeks
of coenzyme Q10
supplementation in elderly people, a
decrease of lipid peroxidation products
and internal micro-viscosity of red blood
cells, and an increase of the activity
of membrane ATP-ase were observed. The
results may indicate the
intensification of oxidative stress in
elderly and point to beneficial effect of
coenzyme Q10 supplementation on structural
and functional parameters of
red blood cells in elderly people.
Phosphatidyl Serine (PS) belongs to a
category of fat-soluble substances
called phospholipids, which are essential
components of cell membranes. It is
found in high concentrations in the brain.
Adults age 50 and older, especially
those with age-related cognitive decline,
may not synthesize enough PS, and
appear most likely to benefit from
supplemental PS.
A double-blind study was undertaken to
assess the efficacy and the safety of
PS supplementation for 6 months in a group
of geriatric patients with cognitive
impairment. A total of 494 elderly patients
with moderate to severe cognitive
decline, were recruited in 23 Geriatric or
General Medicine Units in Northeastern
Italy. Patients were examined before
starting the study, and 3 and 6
months thereafter. The efficacy of PS
compared to placebo was measured on
the basis of changes occurring in behaviour
and cognitive performance using
Plutchik Geriatric Rating Scale and Buschke
Selective Reminding Test.
Statistically significant improvements in
the PS group compared to placebo
were observed both in terms of behavioural
and cognitive parameters. In
addition, clinical evaluation and laboratory
tests demonstrated that PS was
well tolerated. These results suggest PS may
be a promising candidate for the
geriatric patients with cognitive
impairment.
d-Alpha Tocopherol (Vitamin E) is an
antioxidant that protects cell
membranes and other fat-soluble parts of the
body from damage. It is also
known to act through other mechanisms
including direct effects on
inflammation, blood cell regulation,
connective tissue growth and genetic
control of cell division.
Oxidative stress has been implicated in
dementia, a common cognitive
syndrome reflecting a wide spread chronic
progressive disease as an
extension to normal aging process. The
antioxidants have become attractive
therapeutic agents. Among the antioxidants,
vitamin E is the most potent in
the treatment of dementia.
An Indian study was conducted to examine the
role of vitamin E in patients
suffering from dementia in the age group of
66-74 and in age and sex
matched controls. The result demonstrates
that vitamin E supplementation
decreased the latency and increased the P3
amplitude in both the control and
dementia patients. This finding supports
that Vitamin E, because of its
antioxidant property might be decreasing
oxidative stress, which may lead to
improvement in cognitive pool.
Alpha Lipoic Acid is a fat-soluble
compound produced in the body and is
found in some foods such as liver and yeast.
It plays an important role in the
breakdown of carbohydrates, fats and
protein. It is also an antioxidant,
effective against both water and fat-soluble
free radicals. Alpha lipoic acid
may combine with free iron and copper in the
body and protect against the
oxidative damage exerted by these free ions.
The effect of alpha lipoic acid on lipid
peroxidation and antioxidant enzymes
were evaluated in various brain regions of
young and aged rats. Alpha lipoic
acid administered aged rats showed a
duration dependent reduction in the
level of lipid peroxidation and elevation in
the activities of antioxidant
enzymes. There was a rise in the level of
alpha lipoic acid in aged rats after
supplementation of alpha lipoic acid in all
the brain regions examined.
The results suggest that alpha lipoic acid
has a beneficial effect in both
preventing and reversing abnormalities in
aging brain. This beneficial effect
was associated with normalization of lipid
peroxidation and partial restoration
in the activities of various enzymatic
antioxidants suggesting that alpha lipoic
acid supplementation could improve brain
antioxidant functions in the elderly.
Piperine is the extract obtained from
black pepper. It is a known inhibitor of
hepatic and intestinal glucuronidation. In a
study, the effect of combining
piperine was evaluated on the
bioavailability of curcumin in rats and
healthy
human volunteers. Concomitant administration
of piperine produced an
increase in bioavailability of 2000%. The
study shows that piperine enhances
the serum concentration, extent of
absorption and bioavailability of curcumin
in both rats and humans with no adverse
effects. Hence piperine has been
found to aid in improving nutrient
absorption.
In summary, Anti A-G-E is a comprehensive
formulation containing herbs,
amino acids, vitamins and nutrients for
enhancing the antioxidant protection
and contributing to the normal production of
growth hormones. The
ingredients also possess
cognitive-facilitating, immuno-modulatory,
hepatoprotective,
cardio-protective, anti-inflammatory,
anti-stress and anti-lipid
peroxidation actions. Anti A-G-E is a useful
supplement for males and females
to help support healthy aging.
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